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Nested Case-control Study on the Association between Alcohol and the Risk of Proximal Hip Fracture in the Elderly People in Korea.
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Byung Joo Park, Kui Oak Jung, Hye Won Koo, Jong Myon Bae
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Korean J Epidemiol. 1999;21(1):93-103.
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Abstract
OBJECTIVE: To assess the association between alcohol drinking and hip fracture in the elderly people in Korea.
BACKGROUND: Hip fracture is known as one of the major health problems because of its high incidence and serious consequences in the elderly people. The association between alcohol consumption and hip fractures has not been directly evaluated yet in Korea. So we conducted a nested case-control study to investigate the relationship between alcohol consumption and hip fracture in the Korean elderly people.
DESIGN: Nested case-control study from the Korea Elderly Pharmacoepidemiology Cohort (KEPEC), in Pusan, Korea.METHODS Seventy incident cases have been selected since 1993, and 280 controls have been matched with the cases by age and gender among the KEPEC. Average alcohol intake was calculated by multiplying frequency and amount of drinking and unit capacity of each alcohol type. Odds ratios of alcohol intake on the hip fracture and their confidence intervals were computed by using multiple logistic regression with Windows version SAS 6.12.RESULTS The elderly people's drinking rate is lower than the young people in Korea. In univariate analysis, crude odds ratio was 0.26 in male and adjusted odds ratio after contolling for age, smoking status, medication history, physical activity and body mass index was 0.36 in male. So current drinking reduces the risk of hip fracture. Adjusted odds ratio after controlling for age, smoking status, medication history, physical activity and body mass index odds ratio was 0.24 in female with moderate drinking.CONCLUSION We found that alcohol consumption reduces the risk of hip fracture in the elderly Korean. However, we could not explain the plausible mechanism with our data yet.
So, we suggest the further study for elucidating the possible mechanism of the finding including the possible association between nutritional status, alcohol drinking and bone marrow density in the elderly.
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Cohort Study on the Association getween Smoking and Proximal Hip Fracture in the Elderly People in Korea.
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Byung Joo Park, Kui Oak Jung, Jong Myon Bae, Hye Won Koo, Dae Sung Kim
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Korean J Epidemiol. 1998;20(2):246-256.
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OBJECTIVE: To assess the association between cigarette smoking and hip fracture by using the Korea Pharmacoepidemiology Cohort(KPEC).
BACKGROUND: Hip fracture is known as one of the major health problems because of its high incidence and serious consequences in the elderly people. Cigarette smoking, old age, female and low body weight have been reported as risk factors for osteoporosis which is regarded as one of the risk factors for hip fracture. But the relationship between cigarette smoking and hip fracture has not been directly evaluated yet. So we conducted a prospective cohort study to investigate the relationship between cigarette smoking and hip fracture in the Korean elderly.
DESIGN: Prospective cohort study on the 8,994 elderly person aged 65 or more in Pusan, Korea between 1993 to 1996.
METHODS: The Korea Phamacoepidemiology Cohort(KPEC) has been constructed with three kinds of data sources. One is from the Korea Medical Insurance Corporation; Medical Insurance Claims Database and Enrollee's Database. Other sources are from directly constructed pharmacy database and questionnaire data. incidence density and relative risk of smoking for hip fracture were estimated by using the KPEC database. Age and gender specific incidence density was calculated by dividing the number of hip fracture cases by person-years of the follow-up the cohort. Relative risks and their confidence intervals were computed by using multiple logistic regression by Windows version SAS 6.12.RESULTS The level of incidence density in female was higher than that in male, which was increasing with age in both gender. In the multivariate analysis, we observed significant relationship between soking and hip fracture in female(PR=1.94(1.01-3.76)) in the larger amount smoking group, after adjusting for the confounders; age, alcohol drinking, medication history, physical activity and body mass index, the relative risk became slightly decreased to 1.70(0.84-3.46).CONCLUSION Accoding to this result, we suggest that effective anti-smoking campaign should be established as soon as possible for the Korean elderly women.
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Cigarette Smoking, Alcohol Consumption, and Breast Cancer in Korea.
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Dae Hee Kang, Keun Young Yoo, Sue Kyung Park, Hye Won Koo, Jun Suk Suh, Young Chul Kim, Dong Young Noh, Kuk Jin Choe
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Korean J Epidemiol. 1998;20(1):60-69.
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A hospital-based case-control study was conducted to assess the relationship between cigarette smoking, alcohol consumption, and the risk of bgreast cancer in Korea.
Histologically confirmed incident cases of breast cancer(n=146) were selected from the inpatients at the Department of Surgery, Seoul National University Hospital and Borame Hospital during 1994 to 1997. Women ithout self-reported past history of any malignandies were regarded as controls and selected at the same hospitals during the same period(n-153). Information on life-styles including cigarette smoking, alcohol drinking, and reproductive history were obtained by direct interview using standardixed questionnaire. Each case was matched with one control by 5-year age category(n=146). Adjusted odds ratios and 90% confidence intervals were estimated by unconditional linear logistic regression model. For smokers, age at first smoking was significantly associated with the breat cancer risk(adjusted OR=14.1, 90% CI=1.24-364.2). Particularly noteworthy was an increasing tendency of the breast cancer risk with the duration of alcohol consumtion in years aong alcohol drinkers(ptrend<0.1). These findings suggest that cigarette smoking at an earlier age and alcohol intake might contribute to the risk factor of breast cancer in Korean women. Further investigation on the association between genetic polymorphism of xenobiotic metabolism enxymes of environmental carcinogens and breast cancer should be needed.
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